Synthesis of the C-1-C-28 ABCD unit of spongistatin 1.
نویسندگان
چکیده
The synthesis of the C-1-C-28 ABCD fragment of spongistatin is described. Anti-selective boron-mediated aldol coupling of a CD spiroketal ketone fragment to an AB spiroketal aldehyde unit forms the desired C1-C28 advanced intermediate. Other features include the double conjugate addition of a dithiol to an ynone to generate the key beta-keto-dithiane unit required for the synthesis of the AB spiroketal fragment. [reaction: see text]
منابع مشابه
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عنوان ژورنال:
- Organic letters
دوره 5 25 شماره
صفحات -
تاریخ انتشار 2003